However, the multiplicity of technological platforms used as well as the down-sizing of assays, which increases the noise over signal ratio, make reproducibility and comparability of results harder to achieve.
Advances in DNA sequencing technology and the development of high-throughput systems for multiparallel interrogation of thousands of single nucleotide polymorphisms (SNPs) now provide a suite of technological platforms facilitating the analysis of several hundred of Gigabases per day using state-of-the-art sequencing technology or, at the same time, of thousands of SNPs.
However, she was critical with regard to the risks of technological determinism, namely, thinking of technological platforms as the only influencers of human behaviour and organizational change.
With the growing number of large data sets derived from a variety of technological platforms (commercial and "homemade" spotted arrays) cross-laboratory studies are becoming more challenging.
MADGene is thus a means to overcome the heterogeneity of technological platforms and to facilitate inter-studies and inter-species meta-analysis.
Future efforts should explore how to maximize the multitude of technological platforms and utilize target audience preferences for effective dissemination [ 37].
This work has highlighted the benefit of using multiple technological platforms to generate a more complete list of the transcripts present in a given tissue.
Therefore, using multiple technological platforms provides a more complete view of the transcription profile of the tissue or animal being studied, as well as provide increased confidence of the overlapping data.
The notorious heterogeneity of BRCAX tumours has been demonstrated using various technological platforms including gene expression profiling, comparative genomic hybridisation (CGH), immunohistochemistry, LOH and methylation studies (Honrado et al, 2007).
Using multiple technological platforms provides a more complete picture of global gene expression patterns.
