Sentence examples for use of targeted sequencing from inspiring English sources

One common use of targeted sequencing is single nucleotide polymorphism (SNP) detection and validation, where the ability to accurately identify true SNPs and distinguish them from false positives is extremely important.

These two aspects strongly favor the use of targeted sequencing in routine CLL workout.

(b) Coverage analysis of targeted sequencing (Prevalence Cohort).

In 2009, Gabriel et al. (2009) and Bentley et al. (2009) demonstrated the use of targeted next-generation sequencing (NGS) for HLA typing to overcome the problems mentioned above.

However, population genomic analyses outside of these mimicry genes have had less resolution because they have utilized small samples sizes and looked at only a small fraction of the genome, using either targeted sequencing of a few regions of the genome (Nadeau et al., 2012), widely spaced molecular markers (Nadeau et al., 2013), or a combination of the two (Heliconius Genome Consortium, 2012).

Based on a number of studies that used a targeted sequencing approach, there is strong evidence that gene expression quantification using targeted sequencing method is reliable and accurate [ 10, 15].

Other tests use targeted sequencing, mapping only the chromosome regions of interest, or use a qualitative SNP-based approach.

For the validation group, we detected the presence of low frequency mutations using ultra deep targeted sequencing of PCR amplicons from KRAS codons 12/13/146, GNAS codon 201/227, and SMAD2 codon 465 on the Illumina HiSeq 2000.

Recently a comprehensive fine-mapping of the 9p21 region using the targeted sequencing and the reference panel from 1000 Genome project has been performed [ 28].

Here we show that by using targeted sequencing of multiple samples, we can reduce the number of candidate causative mutations to one or two per line.

For example, a lymphoma specimen can be examined for the presence of genetic alterations using targeted sequencing strategies.