Several factors including the use of suboptimal doses of drugs, inadequate or ineffective treatments and poor drug compliance may be the reason for this phenomenon [ 3, 4].
Several factors, including the use of suboptimal doses of drugs, inadequate or ineffective treatments and poor drug compliance may be the reason for this phenomenon.
These include the inconsistent use of standardized ginger formulations and valid questionnaires, lack of control for anticipatory nausea and prognostic factors that may influence individual CINV response, and the use of suboptimal dosing regimens.
The inadvertent use of suboptimal doses of drugs is likely to be one of the key factors contributing to antimicrobial resistance and thereby leading to the wider spread of disease.
Galantamine plasma concentration did not exhibit linear associations with age, cognitive and functional response to ChEI treatment or long-term progression rate; however, these outcomes might have been affected by the use of suboptimal doses of galantamine.
Whether this effect results from a genuine preference for intense sweetness or other factors (e.g., use of a suboptimal dose of cocaine and/or lack of cocaine dependence) has not been established yet, however.
Indeed, the most frequent reasons for the limited use of beta-blockers and prescription of suboptimal doses are advanced age, concern about the potential risk of adverse events or worsening of symptoms, and the sizeable proportion of patients with preserved systolic function.
Moreover, repeated intratumoral injections of suboptimal doses of SFV-enhIL-12 increased the antitumoral response.
This might explain an additive effect of suboptimal doses of resveratrol and rapamycin observed in our animal study.
On the other hand, the possibility of suboptimal dosing could not be unthinkingly discounted since some patients do respond when the dose is raised to the maximum.
