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This effect has been mitigated through the use of strict diagnostic criteria for cases status (see Materials and Methods).
The results of validating the HG registration in MBRN using hospital records are shown in Table 1 and Table 2. Table 1 reflects the validity of the HG diagnosis in MBRN by the use of strict diagnostic criteria indicating severe HG.
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It is obvious that the introduction of strict diagnostic criteria improved the reliability of diagnosis, however it is also obvious that most clinicians do not follow these strict criteria in everyday clinical practice [ 21], but rather prefer an idiosyncratic approach to diagnosis even when using DSM or ICD labeling.
With regard to determining the prevalence of cardiovascular disease in iNPH, the lack of strict diagnostic criteria represents a challenge.
Differences in patient populations and the lack of strict diagnostic criteria at baseline only partially account for this discrepancy.
23 On the other hand, 13 patients (19%) not previously diagnosed with PD received this diagnosis following use of strict clinical diagnostic criteria.
For the purpose of reducing clinical heterogeneity, investigators always use one strict diagnostic definition, such as Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) or International Classification of Diseases 10th revision (ICD-10), to diagnose major depression.
Clinical assessments, maternal serum sFlt-1/PlGF sampling and documentation of maternal/neonatal outcomes are performed at regular intervals, using strict diagnostic criteria for preeclampsia-related conditions and outcomes.
To our knowledge, no studies using strict diagnostic criteria have described the prevalence of diabetic nephropathy and microalbuminuria in early pregnancy in women with type 2 diabetes.
The last is the use of strict financial controls.
These studies validated diagnoses using strict diagnostic criteria, requiring for example specific clinical investigations.
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