Sentence examples for use of small molecules from inspiring English sources

Our results suggest that Fli1 and CTGF are important mediators of the fibrogenic actions of adenosine and the use of small molecules such as adenosine A2A receptor antagonists may be useful in the therapy of dermal fibrosis in diseases such as scleroderma.

This review discusses the use of small molecules for controlling the substrate specificity and product selectivity of P450s.

In this study we examine the use of small molecules to modulate the Wnt and Notch signaling pathways in the Xenopus embryo.

The use of small molecules provides a simple and effective strategy to enhance precise genome engineering applications and facilitates the study of DNA repair mechanisms in mammalian cells.

Given the complexity in the metabolic alterations of cancer cells mediated largely through alterations in mitochondrial function, further research is required to identify more efficient strategies for cancer treatment involving the use of small molecules targeting mitochondrial metabolism.

The use of small molecules to modulate cellular and in vivo systems, sometimes called ''chemical genetics,'' has received renewed interest in the biology community in part because of continuing improvements in synthetic chemistry as well as molecular design.

Interference with these ectonucleotidases by use of small molecule inhibitors or inhibitory antibodies appears to be an effective strategy to enhance anti-tumour immunity and suppress neoangiogenesis.

The use of small molecule inhibitors demonstrated that the activation of the p38, but not ERK, pathway was linked to elevated MMP-2, -9, and -14 expression levels in mesangial cells from integrin α1-null mice.

However, inhibition of only the caveolar pathway whether through the use of small molecule drugs or RNA interference reduces gene delivery efficiency, suggesting that successful polyethylenimine-mediated gene delivery proceeds via a caveolar pathway in HeLa cells.

Several approaches, including the use of small molecule acceptors, novel polymer structures, and tandem cell structures, have been adopted to prepare polymer solar cells displaying high power conversion efficiencies (PCEs).

To test this possibility we made use of small molecule HDAC inhibitors (HDACi).