Sentence examples for use of small molecule from inspiring English sources
Interference with these ectonucleotidases by use of small molecule inhibitors or inhibitory antibodies appears to be an effective strategy to enhance anti-tumour immunity and suppress neoangiogenesis.
Home > Saravanan S. Karuppagounder, Ph.D. My research interests focus on the use of small molecule inhibitors of hypoxia inducible factor prolyl hydroxylases (HIF PHDs) as novel therapeutics for intracerebral hemorrhage.
Several approaches, including the use of small molecule acceptors, novel polymer structures, and tandem cell structures, have been adopted to prepare polymer solar cells displaying high power conversion efficiencies (PCEs).
The use of small molecule inhibitors demonstrated that the activation of the p38, but not ERK, pathway was linked to elevated MMP-2, -9, and -14 expression levels in mesangial cells from integrin α1-null mice.
However, inhibition of only the caveolar pathway whether through the use of small molecule drugs or RNA interference reduces gene delivery efficiency, suggesting that successful polyethylenimine-mediated gene delivery proceeds via a caveolar pathway in HeLa cells.
To test this possibility we made use of small molecule HDAC inhibitors (HDACi).
We recently reported on the use of small molecule-containing LTCs for the targeted destruction of plasma cells (Firer et al, 2003) suggesting that this approach may be applicable for multiple myeloma therapy.
The use of small-molecule angiogenesis inhibitors promises to be a potentially effective method for cancer treatment and possible prevention.
Importantly, the use of small-molecule inhibitors demonstrates that actin dynamism is ultimately needed for granule secretion.
This novelty carries with it an increased development risk compared to tried and tested targets, but this risk could be reduced by the discovery and use of small-molecule chemical tools7,56.
The attraction of large-scale compound screening for life science researchers lies mainly in the technical challenge of assay design and the use of small-molecule effectors for hypothesis-driven research.
