Sentence examples for use of small molecular from inspiring English sources
However, siRNA mediated down-regulation and use of small molecular inhibitors are not always comparable [ 21].
An alternative strategy that yields structural mimetics (class C) involves the use of small molecular scaffolds that replace the entire peptide backbone and align side chains in a spatial arrangement according to the peptide turn residues.
The mitogen-activated protein kinase (MAPK) cascade is a key signal transducer of growth factor induced signals and a widely used target of small molecular inhibitors [ 19, 20].
For the sake of completeness, let us mention here that other homology models have been reported too [45, 46], but as they were used for modeling of small molecular binders, no comparisons can be made here.
Urea and creatinine were used as markers of small molecular weight solutes and β2 microglobulin (β2m) as a surrogate for middle molecular weight solutes.
Nonionic emulsifiers of small molecular weight such as polysorbates are widely used in dairy products.
In recent years, the use of some small molecular agents targeting specific tyrosine kinases of cancer cells shows favorable results, but the improvement is often insignificant to extend the lives of NSCLC patients.
As an alternative approach to increase the hapten density within the drugs of abuse vaccine arena, we envisaged the use of a small molecular scaffold containing a core that would allow diverging three-dimensional projection of the hapten copies to promote spatial separation.
A particular chance for improvements comes from the design and use of stable small molecular additives in combination with optimized and electrochemically stable polymer networks.
However, side effects and acquired resistance have limited in clinical use of these small molecular inhibitors.
Similarly, the use of small sets of molecular markers may fail to detect translocations between Hch and D genomes in a high proportion and thus they only partially fulfil the requirements of our research programs.
