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But since then, the use of serological testing for TB has increased, prompting WHO to do an updated review of the evidence.
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Use of serological tests in India resulted in more DALYs (years of healthy life lost to premature death and illness), more secondary infections and more false-positive diagnoses of TB, compared to the use of microscopic sputum smear analysis or culture.
However, the World Health Organization has recently cautioned against the use of serological tests for the diagnosis of TB disease [ 46].
A new type of patients, with a paucisymptomatic or asymptomatic CD, has been identified by the use of serological tests.
The aim of this unicentre retrospective French study was to evaluate the impact of the use of serological tests in the diagnostic conditions of CD in children.
This study is the first one in France that determines the profile of CD in children since the use of serological tests.
Thus, a systematic use of serological tests on autopsy material may give valuable information on the presence of specific infections in wildlife populations.
By the use of serological tests, specific antibodies against pathogenic serovars similar to those found in animals and humans have been found in reptiles from the same environment.
The first one was constituted by patients who had a CD diagnosis before the use of serological tests (between 1976 and 1992), and the second one after their widespread use (from 1994 to 2007).
Since the initial Finnish study that showed the modifications of presentation of CD in children since the use of serological tests in the 1980s, 6 similar results have been obtained in several European and North-American studies.
The aim of this study was to measure in children the impact of the use of serological tests on the presentation of CD at the time of diagnosis and to answer to the question as to whether it is the appearance of symptomatic forms that has changed, or whether serological tests have given rise to certain forms of the disease that were not diagnosed earlier.
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