Sentence examples for use of sequence conservation from inspiring English sources
ConCavity can be run in two modes depending on whether it makes use of sequence conservation information or not.
Three other methods tested make use of sequence conservation information only: ConSurf (Landau et al., 2005), ET (Mihalek et al., 2004) and INTREPID (Sankararaman and Sjölander, 2008).
Although the underlying cause for the rapid sequence evolution observed in embryonic heart enhancers remains unknown, this unexpected phenomenon has challenged the use of sequence conservation as a criterion for predicting functionally important non-coding DNAs [ 12, 13].
Here we report a novel algorithm that features two innovative changes: 1. making better use of sequence conservation information by grouping the homologous protein sequences into six blocks according to evolutionary distances to human and evaluating sequence conservation in each block independently, and 2. including as many such homologous sequences as possible in analyses.
To predict damaging AAS, we developed a novel algorithm that tries to make full use of sequencing conservation information by dividing homologous sequences into five ortholog blocks and a paralog block.
Thus, in some cases ExAlt could not optimally use evidence of sequence conservation to limit false positive predictions.
We identified ten potential regulatory regions of Olig2 using a combination of sequence conservation across seventeen vertebrate genomes and TFBS density, and perfect HMR conservation.
Efforts to classify UVs are accumulating: several groups have used simple combinations of sequence conservation and the severity of amino acid substitutions [ 24- 26].
Consensus sequences based on these alignments were then used to identify regions of sequence conservation for comparison with known structural and functional elements and alignments were used to construct phylogenetic trees.
Here a new Bayesian statistical approach is used to infer, from patterns of sequence conservation and divergence, various categories of co-conserved residues associated with Arf/Arl GTPase functional divergence.
These studies made use of the high degree of sequence conservation in several PKS domains (reviewed in [ 44]), but which of these genes are responsible for production of the corresponding toxins has not yet been established.
