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However, the etiology of many cases of bronchiolitis and pneumonitis remains unknown despite the extensive use of sensitive diagnostic techniques.
The increased incidence rate across populations in certain periods may be, at least partially, explained by the use of sensitive diagnostic procedures, such as the introduction of ultrasound examination in the 1970s in China and more sensitive imaging techniques (e.g. CT, MRI and PET scan) in recent years.
One possible explanation for the observed increase in the incidence rate of thyroid cancer may be the more frequent use of sensitive diagnostic procedures, such as ultrasound, Doppler examination, CT and MRI scanning, and biochemical markers, during recent decades, which may have increased the detection of thyroid cancers [ 10, 11].
The rapid increase in thyroid cancer incidence in the United States over the past three decades may be related to changes in certain environmental exposures, as well as increased surveillance and more widespread use of sensitive diagnostic tools (Enewold et al, 2009).
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This situation indicates that development of sensitive diagnostic biomarker used in the early stage of HCC will greatly lead to improved survival of patients.
This situation indicates that development of sensitive diagnostic biomarker used in the early stage of ovarian cancer will greatly lead to improved survival of patients.
Early diagnosis is hampered by lack of sensitive diagnostic techniques.
These factors include waning immunity (exacerbated by the change from WCVs to ACVs and, in Australia, cessation of the booster vaccination at 18 months of age) and increased use of more sensitive diagnostic tests, such PCR (4 ).
The limitations of our study arise from the use of insufficiently sensitive diagnostic tests, resulting in a high percentage of false negative samples and, hence, the probability of missing the unconfirmed cases.
This considerably underestimates the true burden of respiratory viruses, as lack of resources precluded the routine use of more sensitive diagnostic methods such as shell vial culture [ 14] and molecular detection methods, and testing of a wider range of viruses.
122 Fifth, changes in classification systems and diagnostic criteria and use of more sensitive diagnostic methods over time (diagnostic drift) may hamper the interpretation of secular trends in incidence.
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