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In addition, with the reduced use of sedative agents in the ICU, many critically ill patients are ventilated with modes of ventilation that allow spontaneous breathing activity.
The process of weaning can be affected by use of sedative agents.
Variables independently associated with 28-day in-hospital mortality were: older age, PaO2 <60 mmHg, cardiovascular dysfunction and less use of sedative agents.
Other examples include the excessive use of antiarrhythmic agents; overenthusiastic feeding with excessive caloric intakes leading to liver steatosis; and excessive use of sedative agents.
Variables independently associated with 28-day hospital mortality were: older age, PaO2 <60 mmHg, cardiovascular dysfunction and less use of sedative agents.
It remains unclear whether these reports reflect true propofol infusion syndrome detected at an earlier and more salvageable stage, or mere associations with the use of sedative agents in general.
Similar(49)
Clinical predictors were often affected by the clinical situations (e.g., using of sedative agents, relying on information of emergency medical service personnel who collected information at a chaotic emergency scene).
Therefore, one might expect to be able to decrease the amount of sedative agents used to achieve patient comfort and 'synch' with the ventilator.
Seven studies reported the impact of sedation protocols on the costs of sedative agents used; all found a reduction in the costs of sedative agents with protocolised sedation, which was reported as significant in four studies [ 2, 9, 17, 19], with values ranging from 22%to94%4% of the cost for non-protocol managed sedation [Table S1 in Additional file 1].
The role of intermittent dosing rather than infusion of sedative agents should also be evaluated.
For example, deep sedation was widely used for many years to ensure patient comfort, but when stopped many patients developed delirium, sometimes even necessitating reintroduction of sedative agents!
More suggestions(15)
use of such agents
use of pharmacological agents
use of tocolytic agents
use of antiplatelet agents
use of autonomous agents
use of hemostatic agents
use of analgesic agents
use of antidiabetic agents
use of neuroprotective agents
use of sedative treatments
use of multiple agents
use of chemical agents
use of sedative antihistamines
use of mobile agents
use of volatile agents
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