After controlling for these effects, the relative risk of heavy alcohol use by first use of alcohol remained significant, although the effect size was somewhat reduced to 2.03 (1.68, 2.45), 1.66 (1.89, 1.41), 1.59 (1.25, 1.59), and 1.00 (reference) for first use of alcohol before 12 years, 12 14 years, 15 17 years, and 18 24 years, respectively.
Experiment 1: Thirty dairy goats received a Short-term Protocol for 5 d using CIDR-G of first use (new devices, n = 10), second use (previously used for 5 d, n = 10), or third use (previously used twice for 5 d each time, n = 10).
We used questions on age began and ended or year began and ended to calculate age at first use, year of first use, number of years since first use, and number of years since last use of oral contraceptives.
Items ask about age of first use, frequency of use, period of use, and time since last use.
Specific drug use variables include lifetime use or nonuse, age of first use, frequency of use during the most recent 30 day period (i.e., number of times used and number of days used).
A supplemental take-home questionnaire collected information on days of use per year, years of use, and decade of first use for the 28 pesticides for which only ever/never use information was collected in the enrollment questionnaire.
The duration of opioid use was counted from the time of first use.
There was no significant association between intensity, duration, cumulative use, or age of first use of alcohol with ESCC risk (data not shown).
It is possible that recall of year of first use, and hence duration of use, may have been more reliable than recall of amount of use.
The format for the DDT was similar to the RBA and included questions about lifetime use and nonuse, age of first use, and frequency of use during the most recent 30-day period (i.e., number of times used and number of days used).
In addition, we matched both biologics and comparator groups for age, gender, propensity score, date of first use of DMARDs, and date of first use of biologics.
