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A weaker association was observed between risk of CDSI and use of second line therapy (p = 0.014).
The studies from Italy and Argentina both reported that second line treatment was not adequate, while the use of second line drugs was not reported in the study from Spain.
XDR TB has not previously been formally reported in mainland China, but given the high prevalence of TB nationwide, the large number of MDR TB cases in the country, and the long-time use of second line anti-TB drugs and fluroquinolones, the existence of XDR TB in China seems inevitable.
Costs associated with drug acquisition, treatment delivery, disease complications, and the use of second line chemotherapy were included.
In the first study [ 52] there was improvement in use of second line uterotonics and escalation of care.
Inappropriate use of second line drugs used in the treatment of TB leads to amplification of resistance and development of XDR-TB [ 10].
Similar(50)
"We are terribly afraid of liberal use of second-line drugs," Dr. Farmer said.
Although there has been multiple studies and several clinical trials (ex ESETT) addressing the use of second-line agents in the treatment of benzodiazepine refractory status epilepticus, there has been little research concerning third-line agents and their effect on outcomes.
On multivariate analysis the factors associated with relapse were age (OR 1.4 per 5-year increase), use of second-line asthma medications (OR 3.7), exposure to cigarette smoke (OR 0.5), and ED visits within the past year (OR 1.2 per 5 ED visits).
The use of second-line chemotherapy after the failure of first-line chemotherapy seems to be a common approach to the treatment of advanced gastric cancer.
Nevertheless, in Lesotho, an innovative community-based treatment model that involved social and nutritional support, strict DOT, and early empiric use of second-line TB drugs was successful in reducing mortality of MDR-TB patients.
More suggestions(15)
use of unstructured line
use of second dose
use of second use
use of auxiliary line
use of commercial line
use of multiple line
use of second generation
use of second opinion
use of second sedative
use of second look
use of central line
use of fixed line
use of active line
use of second trimester
use of overhead line
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