But those that will share a common characteristic: they all sit beyond what mathematician John von Neumann dubbed the "complexity barrier," the dividing line between problems that can be solved using traditional, reductionist methods and those that require a more intuitive, throw-it-up-and-see-what-sticks approach.
The complex multifaceted properties of the host immune response preclude the sole use of reductionist approaches to define clinically useful molecular factors.
Here we identify the neoplastic and non-neoplastic component of lymphoma microenvironment using transcriptomics and proteomics followed by Systems Biology modeling to generates specific hypotheses and then tests these using reductionist methods.
This is due to the use of reductionist and qualitative approaches which is dependent upon the perspective of the assessor(s).
The use of reductionist approaches to business management was successful in the past, when a company's "ecosystem" (products, customers, employees, communication channels, competitors, economic factors,...) was relatively simple and stable.
The interconnection between different cellular processes, such as metabolism and genetic regulation, reflects the importance of the holistic approach introduced by the SB paradigm in replacement of traditional reductionist methods.
GRN analysis is able to supplement the reductionist methods of traditional molecular biology, providing testable hypotheses about the synergistic actions and interactions of multiple molecules [ 59].
It is a reasonable assumption that the transcriptional aspect of the systems biology of fibroproliferative scarring is contained within this collection, to be teased out for interrogation with traditional reductionist methods.
Nobody really can object to this cascade of events, which obeys the reductionist method of science, and nobody seriously questions the dead end that we reach when we try to discover where the quantum field comes from.
Although human performance under psychological stress has been studied extensively, it has been primarily done psychometrically or using reductionist biological methods such as blood cortisol measurements [1].
