Four separate classification schemes using combinations of purebred and mixed breed dogs were used to compare the levels of Canis familiaris 1 in dust samples collected from homes with hypoallergenic versus nonhypoallergenic dogs from an established birth cohort.
This study demonstrates that crossbred animals can be used for genomic prediction of purebred animals using 50 k SNP marker density and GBLUP, but crossbred data provided lower accuracy than purebred data.
The numbers of dogs of each breed were not large enough to allow for analyses by individual breed, but the researchers compared quantities of allergens found in the samples using various categories of purebred and mixed-breed hypoallergenic and non-hypoallergenic dogs.
These results have important consequences for association studies using a population of purebred dogs sampled from multiple locations.
Description: The process to simulate a medium density (60 K) crossbred chip is described in which simulation uses real genotypes of purebred ancestors to simulate genotypes of their crossbred offspring.
We used real genotypes of purebred Microcebus griseorufus and M. murinus from Tsimelahy to simulate 100 local datasets with the same size and composition as in simulation A. We then enlarged each dataset by adding 100 purebred individuals of each species, which we simulated based on purebred genotypes from Hazofotsy and Ambatoabo.
Nevertheless the results confirmed crossbreds of the target breed can be used in genomic prediction of purebred animals which is useful when purebred information is limited, or when the breeding objective is to improve crossbred performance.
However, information from crossbreds of the target breed can be used in genomic prediction of purebred animals, and this is particularly useful when there is limited information on purebreds.
Nonetheless, breeders of other species of purebred animals may use the two terms interchangeably, though thoroughbred is less often used for describing purebred animals of other species.
Brands are applied to animals principally to establish ownership, but they are also used widely for keeping records of purebred lines and for identification in disease control and age differentiation.
