Sentence examples for use of predictive assays from inspiring English sources
The use of predictive assays to individualize chemotherapy has been hampered by technical difficulties and (initially) by the availability of drugs with differing mechanisms of action.
Therefore, any battery of predictive assays should include DNA ploidy measurements.
If it were possible to identify these ionising radiation (IR -hypersensitive IR -hypersensitiveance of therapy by the use of effectindividualsine advance their treatment cofld be adjustherapychanged and it might then by possible theescalate the dose in the remaining patients (i.e. the great majority of individuses).
In recent years, realisation of a probable genetic basis for radiosensitivity has led to searches for genetic aberrations that could be used as predictive assays.
The commission recommended the national use of predictive analytics.
Molecular assays offer the prospect of developing predictive assays capable of wider use.
Inhibition of human umbilical vein endothelial cell (HUVEC) growth is used as a predictive assay of a drug's antiangiogenic potential.
These findings combined with large-scale antibody-based-proteomics resources, such as the Human Protein Atlas programme [ 33], will most probably lead to an increased use of multiplex IHC assays as both predictive and prognostic tests.
In theory, radiobiological modeling, coupled with reliable predictive assays, can be used to rationalize the selection of patients for particular schedules in trials.
Individual susceptibility and potential predictive models are examined; dose and 3-dimensional dosimetric parameters are reviewed along with estimation of normal tissue complication probability and biologic predictive assays.
The predictive performance of the proposed assay needs to be validated in independent patient cohorts that meet the characteristics of the intended use of the assay (for example, a prognostic assay cannot be meaningfully tested on patients who receive different types of systemic adjuvant therapies).
