Sentence examples for use of preclinical models from inspiring English sources

The use of preclinical models enabled us to study the outcome of bevacizumab in combination with chemotherapy on EOC progression (first end point) and survival (second end point).

The use of preclinical models spanning from rodents to non-human primates is essential to apprehend the neurobiological complexity of depression7.

However, the development of new TB regimens is hindered by the limitations in our understanding and use of preclinical models; the paucity of accurate, early surrogate markers of cure, and challenges in untangling the individual contributions of drugs to multidrug regimens in a complex, multi-compartment disease.

The use of preclinical models to test hypotheses is central to cancer research.

This nine-page document contains a paragraph on the use of preclinical models in OA, which surprisingly is lacking in the equivalent European guidelines [ 10].

Accordingly, the clinical translation of anti-CXCL12 agents for use as sensitizers to existing cancer therapies should rely upon the development and use of preclinical models capable of capturing the response to these same therapies in patients.

To date, the majority of preclinical models used to evaluate efficacy of targeted chemotherapeutics are xenografts models, presumably due in part to the four to eight week growth period required to obtain results.

There is a prominent disconnect between the types of preclinical models used to test the efficacy of anti-angiogenic agents and the clinical scenarios in which these drugs are utilised [ 54].

Thus, identification of drugs that target specific molecular features of TNBC and the use of improved preclinical models for this disease are important research priorities.

The notorious difficulty in obtaining human cardiomyocytes (CMs) and propagating them in culture has precluded their use from many drug screening assays and instigated the use of alternative preclinical models.

The use of preclinical rodent models of disease continues to grow because these models help elucidate pathogenic mechanisms and provide robust test beds for drug development.