Recently, there have been several studies investigating the use of peptide hydrogel scaffolds, which are biocompatible and have low immunogenicity, for cartilage tissue engineering.
However, the use of techniques such as peptide engineering, peptide conjugation, and formulation strategies to improve parenteral delivery are paving the way for an increased use of peptides as biologics.
More than one reason to rethink the use of peptides in vaccine design.
The tools of biotechnology include monocloning antibodies and recombinant DNA (rDNA), peptide engineering, generation and use of various antibodies, and mammalian cell culture and transgenic animal techniques.
The use of genetic engineering techniques widens the possible applications of peptides and proteins specifically designed for polymer membrane interactions.
These results have significant implications for the use of these peptides for genetic engineering of fungal resistance in crops.
This work made use of the Peptide Synthesis Core Facility (peptide synthesis) and the Analytical BioNanoTechnology Core Facility (biological and chemical analysis), both of the Simpson Querrey Institute at Northwestern University.
We designed a series of N- or C-terminal truncated variants, mutated analogs, and truncated mutated analogs using peptide-engineering techniques.
They expressed the entire 654 kDa non-ribosomal peptide synthase for valinomycin in soluble and active form, creating a valuable system to produce analogues of the drug by making full use of the genome engineering methods available for E. coli.
This suggests that the desired response of specific cell types to tissue engineering scaffolds could be optimized through a combinatory approach to the use of biomimetic peptides.
