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Oksvold et al. addressed the function of the serine residues at 1046 and 1047 in EGFR (equivalent to Ser1070/1071 in the current numbering) via the use of multiple point mutations.
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The use of multiple points of attachment between molecules leads, in principle, to stronger and more directional supramolecular synthons.
Of note, use of V70 Gy <10% as a single metric alone was not associated with Grade 2+ GI toxicity, suggesting that the use of multiple points on the DVH curve may be important.
This is a general approach for adapting linear methods to model non-linear relationships through the use of multiple points of inflexion (knots) across the modeled time horizon [ 9].
In this paper, we propose the use of multiple-point statistics simulation to integrate the time series of reliable evaporation estimates.
The use of multiple-point statistics predicts long-range connectivity of the structures (measured by local percolation probability) better than standard two-point statistics methods.
This ambiguity derives from the fact that studies suggesting DHIPK2-mediated phosphorylation of Ser-297 of Gro were based on the use of a multiple point mutant in which Ser-297 was mutated together with Ser-194, Ser-196, Ser-285, and Ser-287 [29].
He differentiates between types of perspective, including the conventional form based on a single vanishing point, the use of multiple vanishing points, and aerial perspective.
The use of multiple time points over the 14-day period allowed analysis of the temporal patterns of gene expression profiles.
Regarding the initial values for the parameters, several authors (Ugray et al. 2007; Glover 1998; Dixon and Szegö 1978; Varadhan and Gilbert 2009) suggest to find local maxima starting from widely varying starting points and then pick the maximum out of these, i.e., they suggest the use of multiple starting points (commonly referred to as multistart optimization).
The use of multiple quadrature points renders the resulting flux high-order.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com