Sentence examples for use of mouse models from inspiring English sources
Our use of mouse models in this study has allowed us to analyse in detail the effect of the location of specific germline and somatic Apc mutations to test the 'just right' hypothesis.
The role of the ubiquitination proteasome pathway in breast cancer: Use of mouse models for analyzing ubiquitination processes.
This facility supports use of mouse models to study human diseases such as cancer, assisting with design, generation, and analysis of mice carrying engineered mutations.
Many past and recent advances in the field of iron metabolism have relied upon the use of mouse models of disease.
Thus areas of interest could include (but are not limited to) the genetics and epigenetics of human cancer, tumor-host interactions, tumor metastasis, tumor immunology, and the use of mouse models to dissect mechanisms of tumor initiation and progression.
For example, Food and Drug Administration-mandated pharmacological reviews indicate that adalimumab has at least 1,000-fold 1,000-foldity for murine TNF, relessve to humaffinity; indeed, the low cross-reactivity limited the use oforouse murine in TNF Food and Drelativenistoation approval process33.
Results: We investigate the use of mouse model phenotypes for drug target identification.
However, it was possible to make use of mouse model to do drug research related to 15-delta prostaglandin J2, whose target was a nuclear receptor.
We would like to stress that, depending on the scientific questions, the CAM model may well be used instead of mouse models in preclinical studies.
Indeed, using a combination of mouse models and human iPSC models, such as demonstrated in our paradigm, is required to confidently identify relevant astrocytic targets for inflammatory modulation as a potential treatment strategy for neurodegenerative diseases64, 65.
The recapitulation of the mechanisms underlying the onset of AD is most commonly achieved through the use of transgenic mouse models of the disease state6,7.
