The use of such modest doses in pharmacological neuroimaging studies has the important advantage of avoiding confounds of task-specific effects of drugs with secondary influences due to altered arousal or other systemic or general effects (Honey and Bullmore 2004).
Geron said its trial would require only temporary use of low doses of immune-suppressing drugs.
I found this surprising, for I knew that Artane, a synthetic drug allied to belladonna, was used in modest doses (two or three tablets a day) for the treatment of Parkinson's disease, and that such drugs, in large quantities, could cause a delirium.
Using modest doses and slowly initiating therapy are reported to minimize the frequency of these adverse effects (37).
However, in all published studies so far, THAM has been used at a modest dose, for a short period of time, and not with the aim of full pH correction.
Since most of these studies had technical concerns (e.g., performed in the absence of serum, lack of critical controls (e.g., vehicle to control for contaminating carrier proteins), use of suprapharmacologic doses of rHuEpo, modest proliferative responses for established cell lines), the results from these studies are inconclusive and inconsistent.
We noted this in 22% of our patients, all on modest doses of propofol.
A preliminary in vivo study showed that modest doses of 15 and 16 reduced parasitaemia of mice infected with T. b.
In both arms modest doses of palliative radiotherapy for the treatment of symptomatic adenopathies were permitted.
Hopes in the past have been raised by modest doses of liberalisation, only to be dashed again.
