Sentence examples for use of linkage analysis from inspiring English sources

The use of linkage analysis in combination with genome-wide expression profiling by microarray, also known as 'genetical genomics' [1], enables the genetic control points of gene expression to be mapped to the genome.

Before WES, most gene discovery projects made use of linkage analysis or association studies, which typically identified genomic intervals of 0.5 10 cm containing up to 300 genes (Botstein and Risch, 2003; Glazier et al., 2002).

The lab uses a combination of linkage analysis and whole exome sequencing coupled with functional studies to uncover novel genetic mutations linked to kidney disease.

Out of 31 repeat motives identified in the region of interest, 12 were found to be polymorphic and used for refinement of linkage analysis and haplotype reconstruction (Supplementary Tables 1 and 2).

Using a combination of linkage analysis and exome sequencing, a mutation in the gene TUBB4A (p.Arg2Gly) has recently been identified as causal in the DYT4 kindred by two groups independently (Hersheson et al., 2012; Lohmann et al., 2012).

Recently, Perez et al. used a combination of linkage analysis and whole-exome sequencing to identify a mutation in SLC38A8 that results in infantile nystagmus and isolated foveal hypoplasia (30).

In early 2012, Xiao et al. (2012) reported that they had used a combination of linkage analysis and whole exome sequencing to identify a mutation in CIZ1 (p.Ser264Gly) as the likely causal variant in a large Caucasian kindred with primary cervical dystonia inherited as an autosomal dominant trait.

Since the test for independence is not affected by segregation distortion like the LOD score used by other methods of linkage analysis, a lower incidence of spurious linkage is expected [ 74].

This collaborative study by the ICPCG illustrates the value of consortium efforts and the continued utility of linkage analysis using informative pedigrees to localize genes for complex diseases.

Genomic map of target gene were established through three rounds of linkage analysis using genomic position-ready molecular markers (He et al. 2012).

These results may explain the better power of linkage analysis using this "subgroup" strategy.