Sentence examples for use of laborious from inspiring English sources

Limitations in these reports include relatively small sample sizes, non-contiguous amplicons, partial gene sequencing, multiple PCR for one locus, and use of laborious library preparation and complex sequence analysis methods.

Several linear [ 3- 6] and constrained cyclic [ 7- 10] phage peptide libraries have been sucessfully used to screen for affinity ligands against a variety of targets, all of which were based on use of the laborious, repetitive biopanning procedure.

Although the required data are easily acquired, the calculated parameters are rarely used with PET because of laborious manual procedures and lack of procedural standardization.

Integration of CNTs onto functional devices often involves the use of time-consuming and laborious patterning techniques to obtain spatially selective growth.

Finally, simple approximate expressions for the entropy of gray radiation (GR) are presented, as the exclusive use of numerical integration is laborious.

Traditional genetic engineering methods are template dependent and make extensive but laborious use of site-directed mutagenesis to explore the impact of small variations on an existing sequence "theme".

Most of these studies have deployed RFLP markers, the use of which is a laborious and time-consuming process.

Thus, there is a need to assess whether the use of such an expensive and laborious procedure is required or not.

Because deep sequencing with the Sanger method is laborious, the use of next-generation sequencing may make this approach more comparable to pyrosequencing.

While the use of soft lithography is too laborious, the high energy input of deep UV lithography limits its usage in a variety of material fabrication processes (e.g. for organic thin film transistors).

We present a hollow-structured rigid nanovesicle (RNV) fabricated by a multi-stage microfluidic chip in one step, to effectively entrap various hydrophilic reagents inside, without complicated synthesis, extensive use of emulsifiers and stabilizers, and laborious purification procedures.