Sentence examples for use of ko from inspiring English sources

It was proposed that this contradiction was due to the use of KO mice in the former study, as opposed to the more acute knock-down (KD) approach used in the latter study.

As an alternative approach to the use of knockout (KO) mice, we also utilized intra-hippocampal pre-treatment administration of a GalR1 antagonist to determine if pharmacologic inhibition of GalR1 could modulate susceptibility to seizure-induced cell death.

With regard to methods for confirmation of interactions, the use of knockout (KO) mice or induced overexpression of transcription factors can provide evidence with a high confidence level.

In this study, we examined the pathophysiological roles of IL-6 in the resolution of DVT by the use of Il6 KO mice.

In view of these considerable setbacks with the use of SARM KO mice, we strategically planned and developed a novel in vivo adoptive transfer mouse model system to study the effect of SARM knockdown during an experimental influenza infection.

These experiments also served to emphasize one point about the use of transporter KO mice to study CP transport; that is, unless the transporter is expressed only in CP (or unless a tissue specific KO is used), there may be alterations in plasma substrate concentrations between the null and wild-type which necessitate referencing tissue concentrations to the plasma concentration.

Several major endocrine tissues (e.g., liver, adipose tissue and pancreatic islets) have been shown to be resistant to FGF21 in obese diabetic mice, hence the use of global KO mice might mimic these in vivo diabetic conditions, when particularly attempting to explore the roles of FGF21 during T2DM pathogenesis.

We therefore attribute the differences in our findings and those of Won et al., to the use of global KO strategies, which cause GIT1 knockdown in all cell types throughout development, which is in contrast to the short-term RNAi targeting and pharmacological treatment that we employ here.

This review examines the use of transporter knockout (KO) animals to evaluate transporter function at the choroid plexus (the blood-CSF barrier; BCSFB).

Recently, through the use of a knockout (KO) mouse line, we have shown that FMO1 plays an important role not only in drug metabolism in vivo [23,24], but also in endogenous metabolism, acting as a regulator of energy homeostasis [25].

In summary, we established the use of DAT-KO mice as a model to understand pathological processes and develop novel effective treatments for the recently discovered DTDS.