Sentence examples for use of interim analyses from inspiring English sources

Finally, we recorded the use of interim analyses and data monitoring boards.

Finally, little is known about the use of interim analyses in CRTs altogether [ 40].

Therefore, we systematically reviewed the reported use of interim analyses and DMCs to identify trials in which interim data have been used for reasons other than to make one of the recommendation described above, referring to these occurrences as "extended use of interim analysis" or "extended recommendations by DMCs" for the purposes of discussion here.

The authors describe an endpoint including efficacy and tolerability, and a stopping rule that uses a series of interim analyses in order to reach a conclusion as efficiently as possible without sacrificing reliability.

Our hypothesis was that there would be wide ranges in sponsorship (industry or not), type(s) of intervention(s), use of DSMBs, presence of interim analyses and early stopping rules, absolute risk increase (ARI), and whether or not adequate prior proof-of-principle Phase II studies were done of RCTs that found increased mortality rates of the intervention compared to control groups.

We found wide ranges in sponsorship (industry or not), type(s) of intervention(s), use of DSMBs, presence of interim analyses and early stopping rules, absolute risk increase (ARI), and whether or not adequate prior proof-of-principle Phase II studies were done of RCTs that found increased mortality rates of the intervention compared to control groups.

In the Supplementary material, we provide results showing how the power of the linked-BAR design depends on the number of interim analyses and the prior mean used for the interactions between linked pairs of biomarker and treatment.

Simulation is used to assess the accuracy of both methods for various stopping boundaries and numbers of interim analyses.

Group sequential tests are widely used for interim analyses in randomized clinical trials.

The purpose of the interim analyses is to use the data gathered during the trial to update the allocation probabilities.

A similar model to the one used at the interim analyses is used, except using a classical logistic regression instead of a Bayesian version.