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The use of initial dose intensification in patients with nonseminomatous mediastinal GCT appears reasonable because the results with salvage treatment, even including HD-CT, have been rather disappointing.
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Choice of initial dose and dosing schedule.
* Use an initial dose of the LAI antipsychotic equivalent to oral form.
* Use an initial dose of the LAI antipsychotic equivalent to the previous LAI.
38 The aim of treatment with erythropoiesis-stimulating agents is to achieve a hemoglobin level of 12 g/dL, using an initial dose of 40,000 U of epoetin once a week.
The marketed regimen of efalizumab use was one initial dose of 0.7 mg/kg SC followed by weekly injections of 1 mg/kg SC to a maximum 200 mg.
For parenteral lipids, 90% of the respondents aimed to initiate parenteral lipids during the first 3 days of life, 39% aimed to use an initial dose ≥1.0 g/kg/day and 76% defined the target dose as 3 4 g/kg/day, as recommended.
A minimum therapy duration of at least four weeks was suggested using an initial dose of 300 mg for four days, increasing with 300 mg each four days until a maintenance dose was reached of 600 mg twice daily.
These studies showed that particle toxicity could be ameliorated by dose fractionation, using an initial dose of virus to condition the host such that cytokine responses to subsequent doses were significantly attenuated.
Using an initial dose of 4 mg/kg followed by 2 mg/kg/week, in combination with chemotherapy, the mean peak serum trastuzumab concentration is similar to that in patients receiving trastuzumab alone (101.0 μg/mL at week 8 and 53.4 μg/mL of mean minimum concentration).
The double-blind study in patients with blunt and penetrating trauma used an initial dose of 200 μg/kg, followed by an additional 100 μg/kg if bleeding persisted and a further 100 μg/kg if required, but there is currently no label for rFVIIa in trauma [ 23, 25].
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