An additional 6 participants were excluded due to poor task performance (i.e., less than 60% accuracy in "Truth" blocks, which was close to chance level) or an insufficient number of events in at least 1 of the conditions used in the imaging contrasts (i.e., fewer than 15), or both.
The use of PFC/ICG nanoemulsion-based bimodal imaging contrast agents was investigated for lymph-node mapping using an IVIS Lumina imaging system and a 4.7 T MRI scanner.
In this paper, after discussing the mechanisms and common causes of LV diastolic dysfunction, we provide a practical approach for the assessment of LV diastolic function, focusing on the use of phase-contrast imaging (PC) in the evaluation of transmitral and pulmonary vein flow, and illustrate the different degrees of diastolic dysfunction.
Introduction: In mammographic imaging, use of high contrast screen-film combinations results in under-exposed and over-exposed film areas corresponding to dense mammary gland and breast periphery (BP), respectively, characterised by degraded image contrast.
Other alternative solutions lie in the use of phase contrast MR imaging, coupled with well-established flow field visualization methods to analyze fluid flow.
On the other hand, precise assessment of technical success requires the use of contrast-enhanced imaging, and is generally performed using contrast-enhanced CT (CE-CT) and/or contrast-enhanced MRI (CE-MRI) within 1 week after the procedure [4, 9, 10, 11, 12].
The use of intracellular motion as an imaging contrast agent, together with its label-free and non-invasive character, provides an opportunity to develop a new three-dimensional tissue screen for many types of drugs in early drug discovery.
In optical breast imaging, two techniques can be distinguished, i.e. optical imaging without contrast agent, which only makes use of intrinsic tissue contrast, and optical imaging with a contrast agent, which uses exogenous fluorescent probes.
Unenhanced CT imaging is typically utilized, because the use of iodine contrast interferes with radioiodine imaging and therapy.
Potential applications of using FNDs as a dual imaging contrast agent for combined fluorescence and photoacoustic imaging modalities may become possible in future if photocleavable linkers are used for synthesizing the FND-GNP conjugates.
