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A recurring problem in retrofitting historic windows is that most traditional means of improving their energy efficiency, e.g. the use of IG units, is often unavailable due to structural and esthetic concerns.
However, in view of the lack of controlled data on its safety, the use of IG is currently not recommended in pregnant women.
The Italian Diabetes Pregnancy Study Group has therefore promoted a national survey to collect data on the use of IG in women with pre-gestational diabetes.
However, in our series, the use of IG throughout pregnancy was not associated with higher birthweight or any change in neonatal outcome.
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Since we do not know precisely the Ig-VH genes used by RF-secreting B cells, it is not possible to relate RF to the use of Ig-VH genes.
B cells regenerated well in both patients, and the repopulated B-cell repertoire was characterised by a polyclonal and diverse use of Ig-VH genes, as expected in adult individuals.
The most promising approach reported in the literature is the use of enteral Ig as it has been described successful in four immunocompromised patients: two children with small bowel transplantation [ 13] and two adults, one with cardiac [ 17] and the other with renal transplantation [ 11].
Different strategies have been tested, from the adjustment of immunosuppressive treatment to the use of oral immunoglobulin (Ig) or antiviral drugs, but with controversial results [ 2].
For the intracellular detection of NCR ligands, we initially made use of NCR-Ig fusion proteins.
This project has demonstrated the feasibility of using a specially designed cascade training to build the skills of primary care workers in the use of mhGAP-IG.
Our findings may be important for development of new therapeutic strategies, for example the use of NCR-Ig fusion proteins with aim of inhibit tumor growth [ 38].
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