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Diabetes was defined by fasting glucose > = 126 or the use of hypoglycemic medication or insulin.
Diabetes was defined as fasting glucose of ≥ 7.0mmol/L (≥ 126 mg/dL) or use of hypoglycemic medication.
Serum glucose was measured using a Beckman Synchron LX20 analyzer and diabetes was defined as a fasting glucose ≥ 126 mg/dL, non-fasting glucose ≥ 200 mg/dL, or a self-reported history of diabetes with concurrent use of hypoglycemic medication.
Diabetic subjects were identified from self-reported doctor's diagnosis and the reported use of hypoglycemic medication; subjects were also classified as diabetic if they reported use of diabetes medication without reporting a diagnosis of diabetes.
Type 2 diabetes was defined as self-reported type 2 diabetes, fasting glucose >126 mg/dl (for millimoles per liter, multiply by 0.0555) at any examination, or use of hypoglycemic medication.
Prevalent and incident diabetes was defined by 1) glucose ≥126 mg/dL when participants had reported fasting ≥8 h before venipuncture; 2) glucose ≥200 mg/dL when last oral intake was <8 h from venipuncture; or 3) use of hypoglycemic medication.
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Our outcome was clinically incident diabetes, identified through the use of hypoglycemic medications, diagnoses for hospitalizations and causes of death.
Current use of hypoglycemic medications (oral agents and insulin) was determined during the baseline interview.
We ascertained incident diabetes among 3,740 Cardiovascular Health Study participants (1992 2007) based on the use of hypoglycemic medications, fasting glucose ≥126 mg/dL, or nonfasting glucose ≥200 mg/dL.
With higher HbA1c levels, the use of hypoglycemic medications was more prevalent: 29.8, 39.2, and 37.4% in the second, third, and fourth groups, respectively (P < 0.001).
Diabetes was defined by International Classification of Diseases, 9th Revision (ICD-9) diagnosis and use of hypoglycemic medications (measured at baseline and 12 15 months).
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