Sentence examples for use of high dosing from inspiring English sources

Dosing simulations for amikacin supported the use of high dosing regimens (≥25 mg/kg) and extended intervals (36 to 48 h) for most patients to achieve the pharmacodynamics/pharmacokinetics target of peak/MIC ≥ 8 for efficacy and the lowest probability of target attainment (PTA) of a minimal concentration ≥ 2.5 mg/L for toxicity.

Our patient showed a fluctuating clinical course despite prolonged use of high dose prednisolone.

Thus, the "anti-receptor" drugs rather expensive and require the use of high doses.

Use of high doses of verapamil in preventive treatment of cluster headache (CH) is limited by cardiac toxicity.

However, use of high dose CHX has adverse side effects such as tooth staining and calculus formation.

Experimental studies in the animal have not been designed to specifically address the use of high doses of botulinum toxinum.

However, maternal use of high doses of fluoxetine throughout pregnancy may be associated with a risk for low birth weight.

Four randomized trials investigated early use of high doses of corticosteroids for the prevention of ARDS in septic shock patients [90 92] or in patients with confirmed ARDS [93].

This would limit the use of high doses of exogenous EPO that can overwhelm the tissue-protective properties of EPO with its adverse side-effects.

The use of high dose gonadotropin treatment in our study groups seems to be the only explanation for their subsequent successful outcome.

Independent predictors of mortality were the initial severity assessed by the GMSPS (p = 0.001) and use of high doses of vasoactive drugs evaluated by the vasoactive-inotropic score (p = 0.026).