Experimental studies in the animal have not been designed to specifically address the use of high doses of botulinum toxinum.
However, maternal use of high doses of fluoxetine throughout pregnancy may be associated with a risk for low birth weight.
Thus, the "anti-receptor" drugs rather expensive and require the use of high doses.
Use of high doses of verapamil in preventive treatment of cluster headache (CH) is limited by cardiac toxicity.
This would limit the use of high doses of exogenous EPO that can overwhelm the tissue-protective properties of EPO with its adverse side-effects.
Considering the use of high doses, the cardiac safety of verapamil therapy was specifically studied in one series that included 108 CH patients treated by verapamil with systematic electrocardiogram (EKG) assessment [9].
Independent predictors of mortality were the initial severity assessed by the GMSPS (p = 0.001) and use of high doses of vasoactive drugs evaluated by the vasoactive-inotropic score (p = 0.026).
Four randomized trials investigated early use of high doses of corticosteroids for the prevention of ARDS in septic shock patients [90 92] or in patients with confirmed ARDS [93].
The early use of high doses of corticosteroids for the prevention of ARDS in septic shock patients or in patients with confirmed ARDS significantly reduced the duration of mechanical ventilation but had no effect or even increased mortality.
In fact administration of an excessive dose of contrast agent due to poor experience of the operator can affect the diagnosis: the dose depends on the target organ but also on the characteristics of the equipment used, the use of high doses of contrast agent results in excessive hyperechogenicity of the parenchyma which disturbs the identification of small traumatic injuries [7].
But Stephen Barrett, who runs the anti-fraud Web site Quackwatch and has long opposed the use of high doses of vitamin C, remains skeptical that this will lead to practical applications in humans: "I hope this will not touch off a rash of people to offbeat practitioners to get intravenous vitamin C".
