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This research raises important questions about the use of generic quality of life measures among survivors of critical illness.
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The large number of genotypes scored in a study such as this requires the use of generic approaches to quality control, allowing SNPs to be excluded where the quality of genotyping is in question.
One general recommendation is to use a generic quality of life questionnaire to compare results from different diseases and conditions.
Wandell [ 39] found that beta-blockers with or without miotic agent had no negative impact on health related quality of life using a generic quality of life instrument.
Over time, the use of generic instruments in national quality registries can facilitate the comparison of HrQoL of children with chronic health conditions.
Easton et al. [ 43] also used a generic quality of life questionnaire (Toddler Child Quality of Life Questionnaire – ITQOL) and found that caries-free preschool children showed better quality of life reports compared with those who had acute or chronic caries with pain.
While broader outcomes have been measured in some research samples of ED patients using generic quality of life (QoL) instruments, including the Short-Form-36 (SF-36), the Nottingham Health Profile (NHP) and the World Health Organization Quality of Life Instrument - Brief Version (WHO QoL-Bref) [ 2], they have several limitations.
The aim of the focus group discussions with consumers and interviews with providers was to gather insights into peoples' understanding of quality and use of generic medicines rather than reaching consensus on quality of generic medicines.
We likewise used no generic quality of life questionnaire, since it is considered that the usual components of such questionnaires have been sufficiently evaluated.
The rationale for using both WOMAC and the SF-36 for this trial is that a combined approach using both generic quality of life and knee specific health status measures is considered likely to prove best for knee-related problems [ 26].
Considering that the evaluation of quality of life of substance users is usually performed with different tests, the objective of this study was to establish the concordance among the HRQoLDA, the DUQOL (which is a specific assessment tool for substance use), and the WHOQOL-BREF (a widely used generic quality of life measurement instrument).
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