Sentence examples for use of fixed dose from inspiring English sources

Furthermore, the use of fixed dose combinations of antiretrovirals gives little scope for dose-modification as a strategy for managing these interactions.

Basic questions such as the relative size of the private market across HBCs, specific dosage strengths used, use of fixed dose combinations (FDCs) or loose pills, and leading manufacturers in this space have not been documented, despite the fact that the private markets in HBCs are not new and continue to serve, in certain countries, as major channels for treatment by patients.

There have been no such studies in resource-limited settings where risk is arguably increased as a result of less laboratory monitoring, high rates of background illness (which may result in adverse effects being missed), lack of affordable alternative treatments, use of fixed dose combinations (that offer less flexibility for managing interactions) and lack of pharmacovigilance data.

This finding may be also partly related to the availability and increasing use of fixed dose combinations containing FTC, which have been shown to implement adherence [ 33, 34].

Hence, the use of fixed dose combinations in our study, may not have contributed substantially to the low levels of concerned drugs.

Interestingly, the use of fixed dose combinations has been shown to significantly improve compliance by reducing pill burden [ 24, 25], which results in higher rates of treatment target achievement and lower hospitalisation rates.

The editorials accompanying the studies by Simon and colleagues and by Morelli and colleagues emphasized the possible limitation of these investigations related to the use of fixed doses of the drugs that are supplemented by noradrenaline, and furthermore highlighted the potential of AVP or terlipressin as a first-line vasopressor rather than as a last-resort therapy [ 41, 42].

The current evidence for tolvaptan in AHFS is primarily restricted to the use of fixed-dose administration rather than alternative dosing approaches, such as dose adjustment based on clinical response.

Free healthcare assistance offered by the Spanish Health System and the widespread use of fixed-dose combinations for more than 30 years could have contributed to the low rate of drug resistance in Spain.

However, a recent systematic review and meta-analysis indicated that the use of fixed-dose combination formulations does not improve treatment outcomes among patients with active tuberculosis [ 43].

Use of fixed-dose, single-pill combination treatment has recently been shown to markedly improve patient compliance [ 36], and thus, current recommendations advocate the use of fixed-dose combinations (including triple combinations, when necessary) to improve BP control and reduce associated morbidity and mortality [ 3].