Sentence examples for use of extended infusion from inspiring English sources

Also, worthy of investigation is whether the use of extended infusion of meropenem and the combination of beta-lactam antibiotics with aminoglycosides are associated with less risk of the emergence of resistance.

Another, less expensive strategy in these cases may be the use of extended infusion, over 3 to 4 hours, of standard multiple daily dosing.

A patient-based simulation for the carbapenems demonstrated that utilization of extended infusions increased the probability of achieving bactericidal exposures for multidrug-resistant P. aeruginosa (Table 1) [ 17].

Shown is the effect of extended infusion of carbapenem antibiotics on the bactericidal cumulative fraction of response against multidrug-resistant Pseudomonas aeruginosa [17].

- Patients with augmented renal clearance have a high probability of target non-attainment, even with the use of an extended infusion strategy.

Use of extended or continuous infusion maximizes the time during which drug concentrations are above the MIC (8, 9).

The use of extended (or continuous) infusions of β-lactam antibiotics increases the fT>MIC and may potentially improve overall efficacy (6, 11).

Although the time above MIC for more resistant strains (such as those with MICs of 8 or 16 μg/ml) is considerably reduced when conventional doses and/or administration techniques are used, drug concentrations can be maintained above these elevated MICs by both increasing the dose and using an extended infusion.

For lipophylic antibiotics such as fluoroquinolones, the volume of distribution is grossly unchanged and clearance depends on hepatic function.> For time-dependent antimicrobials such as beta lactams or glycopeptides, the use of continuous or extended infusions of antimicrobial is able to increase the fT > MIC.

Fig. 2 Use of extended hemodynamic monitoring.

If available, the use of extended CT and PET FOVs is recommended.