With 20% of the African people being homozygous for the slow allele, CYP2B6*6, use of a dosing algorithm guided by inclusion of pharmacogenetic data could translate to a significant clinical intervention for the safe use of efavirenz in Africa.
The proposed work is designed to generate a robust dataset of out-of-field dose measurements which can be used for the development and validation of dose algorithms.
Although there was no statistically significant difference in the rates of hypoglycemia with using either dosing algorithm, the simple algorithm had 53 episodes of hypoglycemia in 19 patients, whereas the carbohydrate counting group had 37 episodes in 19 patients.
The findings suggest that the complexity introduced when prandial insulin is added, both for the individual and the physician, can be minimized by the use of a simple dosing algorithm, thereby removing one of the potential barriers to the introduction and optimization of prandial insulin.
Therefore another explanation for the high incidence of neutropenia in this study may be the use of a MMC dosing algorithm based upon weight, rather than BSA.
Because microspheres can be assumed to be a permanent implant, the use of appropriate dose calculation algorithms allows quantitative 90Y PET images to be converted into absorbed dose maps.
In addition, we propose the use of model-based interventions, such as different dosing algorithms, to improve the outcome of therapy and the safety profile of current and novel drugs in high-risk patients.
We examined the use of a computerized insulin dosing algorithm to manage hyperglycemia with particular attention to frequency and conditions surrounding hypoglycemic events.
We present the report of our 9-years' experience with the use of an algorithm for dose adaptation of prolonged continuous HSS infusion in patients with refractory ICH.
Different methodologies have been proposed to estimate the effective dose when RPG are used (ERPG), like applying a correction factor to the dose of a standard Hp(10) dosimeter worn above or below RPG (single dosimetry), or the use of an algorithm combining the dose from two of them: one worn above RPG and the other one worn below (double dosimetry).
