Using an appropriate definition of, the computation of different scheduling policies can be formulated as the aforementioned optimization problem as follows.
This also open the door to lot of different scheduling strategies that cannot be considered using classical architecture.
Irinotecan is routinely administered intravenously either as a single agent (Cunningham et al, 1998; Rougier et al, 1998; Rothenberg et al, 1999; Van Cutsem et al, 1999) or in combination with bolus or infusional 5-FU/FA regimens, using a variety of different schedules (Douillard et al, 2000; Saltz et al, 2000), for the treatment of advanced CRC.
Obviously, efficacies of different schedules, combinations and brands may differ.
You can surf the web for examples of different schedules.
For a given combination tested in multiple trials, we take into account that p may be different due to the use of different dose, schedule or cancer subtype on each trial.
Further improvements in toxicity, response rates and survival may result from the use of an alternative taxane such as docetaxel, from the incorporation of other agents or from the use of different treatment schedules.
Newer approaches that might reduce rates of anaphylactoid reactions are clinically needed, and this might include the use of different acetylcysteine infusion schedules such as we have recently described 18.
This difference could be at least partly explained by inconsistent definitions of pain flare, use of different radiation dose schedules, lack of adjustments for steroid medication or opiate medication, and variations in the time periods at which pain intensity was recorded to capture the flare event [ 17].
