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Exact(6)
However, this practice raises major concerns since the use of deep sedation has been incriminated in brain dysfunction [4, 5] and may contribute to increase the prevalence of delirium [6 8] and mortality [9, 10].
The only large RCT published on this subject [18] included patients with ARDS only, who present specific characteristics: long respiratory recovery, use of deep sedation and neuromuscular blockades; in consequence, their results could not be generalised to the overall PICU population.
Another study indicates the use of deep sedation in the form of midazolam, fentanyl, and propofol for pain reduction [ 9].
We also assessed the factors influencing the success rate of the procedure and ways to improve performance, analyzing the complementary aspects relating to the use of deep sedation.
Although ours was an observational study on the controversial issue of the routine use of deep sedation for colonoscopies, it had the advantage of referring to a recognized target (i.e. 95% cecal intubations in colonoscopies for screening purposes).
According to the EAPC framework, in the absence of refractory symptoms, the use of palliative sedation in the end of life is characterised as "abuse": "This [abuse of palliative sedation] may occur by the deliberate use of deep sedation in patients who have no refractory symptoms" (p. 582) [ 4].
Similar(54)
The present study on the experience of a single centre focused on estimating the overall completion rate of colonoscopies performed under routine propofol sedation at a large teaching hospital with many operators involved, and on assessing the factors that influence the success rate of the procedure and how to improve this performance, analyzing the aspects relating to using of deep sedation.
For FB one reason may be related to sampling technique and the use of deeper sedation, allowing more accurate targeting of the suspicious lesion.
While some may remain concerned with the use of deeper sedation and general anesthesia (as in the case of our rigid bronchoscopy cases), Hetzel et al. study also showed that over 45% of their patients underwent general anesthesia with also reportedly no associated complications [ 5].
Evidence does suggest that dexmedetomidine may allow for avoidance of deep sedation and use of benzodiazepines, factors both observed to increase the risk for developing delirium.
The purpose of this study is to evaluate complications of deep sedation with propofol without the use of intubation during second trimester surgical terminations in an inpatient teaching institution.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com