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The use of computational simulation to examine common clinical problems including single ventricle physiology and the associated surgical approaches, the effects of pacemaker implantation on vascular occlusion, or delineation of the biomechanical effects of implanted medical devices is now routinely appearing in clinical journals within all pediatric cardiovascular subspecialties.
The increasing use of computational simulation experiments to inform modern biological research creates new challenges to annotate, archive, share and reproduce such experiments.
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In this review, we examine the role of computational simulation, using biophysically detailed models of cardiac electrophysiology, in predicting the risk of drug-induced pro-arrhythmic effects.
Structural modeling supported by experimental probing has offered ideas based on the symmetry features of the molecules in this family [21], [22], and the powerful approach of computational simulation using high resolution structural information was applied to the exploration of the functional mechanisms of proteins with a LeuT-like structure fold (e.g., see [10], [16], [23] [33].
The behavior of the façade was compared with different traditional constructive systems, using the results of computational simulations performed with the Design Builder software.
We reached this signature sequence using a combination of computational simulations to obtain optimized amino acid sequences that were then confirmed by binding studies in vitro.
"Braxton's work provides fresh insight on the acoustics of large Venetian churches through the use of modern computational simulation techniques," says David T. Bradley, a physicist at Vassar College in Poughkeepsie, New York.
In this paper, we present a mechanistic explanation through the use of a computational simulation.
Finally, an effort was made to investigate the possibility for solid-state diffusion of carbon in austenite, under the short heating times imposed by laser treatment, with the use of computational kinetics simulation.
To facilitate this process, the use of computational and simulation models to predict the response of cancer cell lines to drug compounds has grown in recent years.
A series of computational simulations were performed using a multiphysics software COMSOL for four different models shown in Fig. 2.
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