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Since then, hundreds of new CNVs have been described in the human genome thanks to the use of comparative genome analysis and array technologies.
We conclude that activation of ERK is both necessary and sufficient to trigger expression of DUSP6/ MKP- 3. The use of comparative genome analysis to detect non-coding DNA sequence conservation within the 5′-flanking regions of orthologous genes across species is a useful tool in the identification of key regulatory elements [ 33].
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In recent years, the use of comparative genomic approach to study genome size variation within a phylogenetic framework has shed much light on the genome size variation in closely related species, such as studies in cotton [ 17, 18, 20, 21, 32], in rice [ 10], and in Drosophila [ 6, 22].
To address these issues we used a combination of comparative genome hybridisation (CGH) and serial analysis of gene expression (SAGE) to identify candidate genes on 1q.
The current availability of well over 1000 complete bacterial and archaeal genomes permits the use of comparative genomics methods to locate the substrates for orphan TOMMs while simultaneously broadening the search for previously unknown families of post-translationally modified peptides.
The proliferation of genome sequencing and assembly has made possible the use of comparative genomics approaches for TFBS discovery.
Bratke and McLysacht [ 59] made use of comparative genomic information and synteny conservation to investigate HGT in pox genomes [ 59].
Conserved gene context is used in many types of comparative genome analyses.
It is not purported to model the ancestor, even though it, same as the ancestral genomes, may be constructed using methods of comparative genomics, and even though minimal genome may be enriched in ancestral genes.
The CNMS markers provided encouraging implications for their use in comparative genome mapping and understanding of evolutionary complexities in rice and other members of grass family.
A series of seventeen strains of E. coli RS218-derived genomislandsnds (RDIs), using a comparative genome analysis of meningitis-causing E. coli K1 strain RS218 (O18 K1 H7), together with a plasmid-cured E. coli K1 strain RS218 were obtained from the laboratory of Kwang S. Kim (Johns Hopkins University) as previously described [ 12, 14, 15].
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