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For evaluation of primary osteoporosis prevention, efficacy in the prevention of bone fracture is the prerequisite – before the use of bone mass as the main evaluation criterion.
The use of bone mass measurements for prognosis depends upon the accuracy.
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Bisphosphonates are a class of drugs that are widely used to inhibit loss of bone mass in patients.
Control of osteoblast function and regulation of bone mass.
Bone mineral density (BMD) is used to follow gain or loss of bone mass but cannot detect changes within a short period of time.
Inhibitors of this pathway, namely bisphosphonates and statins, are used in therapies to prevent loss of bone mass and to lower blood cholesterol levels (Buhaescu and Izzedine 2007).
To circumvent these side effects, specifically osteopenia, the patient required treatment with alendronate (a bisphosphonate medication used to prevent and treat loss of bone mass), calcium and vitamin D. Her serum immunoglobulin E was mildly elevated.
As endometriosis is an estrogen-dependent disease, this approach typically results in relief of symptoms; however, due to the potent suppression of endogenous estrogen production, GnRH analogues are associated with hypoestrogenic symptoms and loss of bone mass, limiting their use to short-term therapy or requiring add-back therapy [ 25].
Bisphosphonates are stable pyrophosphates that prevent the loss of bone mass and are used widely to treat a range of diseases with excess bone resorption, such as bone metastasis, hypercalcemia of a malignancy, and Paget's disease [13 16].
Any of 3 parameters can be used in making this determination: continuing loss of bone mass on therapy, failure of therapy to suppress biomarkers of bone turnover, or the occurrence of additional fractures on therapy.
It is well known that loss of bone mass, quantified by areal bone mineral density (aBMD) using DXA, is associated with the increasing risk of bone fractures.
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