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This is the first report relating to the use of backbone-modified PNAs as anti-miR agents.
This model differs from the Clementi-Onuchic model mainly in the use of backbone-backbone and side-chain-side-chain hydrogen-bond assignments to define native contacts between residues, with H-bonds assigned according to an energy threshold.
The use of backbone-modified PNAs can therefore be viewed as a strategy for delivery of PNAs in an efficient way that is less sensitive to the condition of the medium, as demonstrated by Ly and co-workers in several papers.
The overwater monitoring platform which communicates with other nodes using GPRS plays the role of backbone node.
Prior to that time, use of the backbone was subject to an "acceptable use" policy, established and administered by NSF, under which commercial use was limited to those applications that served the research community.
The use of the backbone cables which are mandatory in conventional TDOA positioning systems can now be avoided.
This chapter will specifically focus on the use of polymeric backbone to develop a library of novel materials and their subsequent biomedical applications.
The observation of selectivity with these molecules suggest that epoxide warheads could be targeted to the NS2 autoprotease to increase both activity and selectivity through the use of a backbone scaffold not derived from peptide substrates.
Today only 2% or so of American homes have high-speed Internet connections that can make use of fast backbones.
It should also be noted that there exists a line of work that attempts to overcome the use of a fixed backbone by iterating between cycles of fixed backbone design and backbone improvements, e.g. Kuhlman et al., (2003).
One approach to this problem is the use of a parameterized backbone, which allows the systematic exploration of families of structures.
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