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The use of archived samples raises a number of important ethical challenges.
The use of archived samples deriving from radical prostatectomy was approved by the Ethics Committee of Innsbruck Medical University.
This distribution of research resources raises important issues about the use of archived samples, sample ownership and ethics review by multiple committees.
Taken together, these factors mean that GWA studies such as MalariaGEN need to rely heavily on the use of archived samples.
Genomics research raises ethical and governance issues about sample export and ownership, about the use of archived samples and about the complexity of reviewing such large international projects.
The board can waive the informed consent requirement under specific circumstances that include assessment of minimal risk to the patient, of patient personal autonomy, and of the practicability of obtaining consent (eg for use of archived samples).
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GB performed selection of archived samples and clinical data collection.
BW and WBH performed selection of archived samples and scored the immunohistochemistry staining.
All ethics committees reviewing the MalariaGEN studies approved the inclusion of archived samples in the prospective genomic study.
The study was approved by the Institutional Review Board of The Johns Hopkins Hospital, which waived the need for obtaining decedent informed consent for use of archived myocardial samples and records.
However, the use of archived serum samples in the present series precluded the exploration of genetic characteristics of HHV-8 strains in the non-Amazonian groups.
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