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It is sometimes claimed that the use of animal data for estimating human risk does not provide strong scientific support.
The use of animal data to quantitatively predict risk in human was limited.
We found limited use of animal data to quantitatively predict human risk and listed the methods from the literature that performed analytic linkage.
One conclusion from the study was that the use of animal data is more convincing when based upon studies from multiple similar substances and multiple species [ 4].
The authors acknowledged several limitations to their approach, particularly the use of animal data and the use of LD50s rather than NOAELs.
The lack of adequate human exposure-response data renders the use of animal data essential in order to assess the harmful activity of specific environmental stressors in humans.
Similar(52)
The analysis of acrolein risks for respiratory effects examined the applicability of using dose response modeling of animal data to estimate the benefits to humans.
Proposed methodologies involved analysis of data-rich pollutants and application of this analysis to other pollutants, using dose response modeling of animal data for estimating benefits to humans, determining dose-equivalence relationships for different chemicals with similar health effects, and analysis similar to that used for criteria pollutants.
The first is the use of biomarkers to enhance extrapolation of animal data to human exposure situations in establishing risk standards.
A secondary objective was to assess the relevance of animal data to the use of ototopical drops in clinical situations involving humans.
Analyses of animal data were performed using the R statistical software package [ 11].
More suggestions(15)
use of research data
use of animal organs
use of animal proteins
use of animal parts
use of animal products
use of animal carcasses
use of animal by-products
use of web data
use of animal brains
use of animal vaccines
use of animal bones
use of animal subjects
use of animal characters
use of customer data
use of polygraph data
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