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Toby has Down syndrome and complications that would make the use of alternative drugs dangerous.
Approaches to overcome antimonial resistance include use of alternative drugs which as mentioned earlier, are not devoid of limitations, or combination therapy having synergistic effects to check the further development of resistance [8] [12].
The greatest experience with the use of alternative drugs has been with the POMB/ACE regimen (cisplatin, vincristine, methotrexate,bleomycin, actinomycin-D, cyclophosphamide, etoposide) with two institutions treating 339 patients with MGCT over a 20-year period with a median follow-up of 8 years (Bower et al, 1997).
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There are, however, clinical considerations and manufacturing challenges that might militate against the potential efficiency savings in administration costs from reformulating biologic products or making use of alternative drug delivery systems.
In addition, the use of alternative drug delivery systems [54], [55] may be precluded by the long-term bioactivity of neurotrophins under physiological conditions, which is currently unknown.
Furthermore, in the presence of unexpected toxicity during conventional anticancer treatment, the simultaneous use by the patient of alternative drugs should be suspected.
But the increasing cloud being cast over drugs like Adderall, which contain amphetamine, and the cumbersome process for prescribing controlled substances like these to children (not to mention the stigma associated with their use) may be enough to boost sales of alternative drugs that do not contain the same active ingredients and are not sold as similarly restricted substances.
Due to a lack of data about the prevalence of the use of alternative medical drugs in the studied population we assumed a prevalence of 50% of the use of CAM drugs in in the studied population.
6 7 This justifies the use of alternative tocolytic drugs.
The high incidence of ESBL-positive Enterobacteriaceae in deployed soldiers in Mali suggests the use of alternative antibiotic drugs in case of systemic infections.
The use of alternative therapeutic drugs, such as benzodiazepines, will reduce the chance of extra pyramidal adverse effects [ 96] and decrease the risk of intoxication [ 97].
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