Overall, difficulties maintaining the extracorporeal circuit in mTPE required the use of additional disposable sets, high doses of heparin and nursing time.
For minocycline, adverse drug effects led to a doctor visit in 48.2%, discontinuation in 38.2%, the use of additional medication in 32%, a dose change in 31.6%, missed work in 1.1%, and hospitalizations in 1.0% of the patients who reported a medication side effect.
The jugular cannula was used to administer additional doses of anesthetics and saline for fluid balance as needed throughout the experiment.
Patients who are maintained on buprenorphine (for opioid dependence) further use additional doses besides its maintenance dose.
Although consensus has emerged supporting the use of high-dose methylprednisolone or prednisone for initial treatment of aGVHD, practices differ among centers with respect to the initial glucocorticoid dose, the use of additional immunosuppressive agents, and the approach to withdrawal of treatment after initial improvement.
Furthermore, the use of escalating doses facilitates the use of additional statistical tools such as trend analysis.
Antibiotic name, dose, interval, and duration of infusion, as well as use of additional antibiotics were also recorded.
The additional use of quetiapine at doses between 25 and 600 mg/d was established in a further meta-analysis only in the treatment of generalized anxiety disorder [ 16].
Additional doses of these agents were used if anesthesia lightened during experiment.
Additional doses of pentobarbital (2 mg/kg) were used whenever required.
