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One year average use of active vitamin D and phosphate binder were also calculated.
Chinese guidelines particularly recommend use of active vitamin D in managing osteoporosis.
Next, in the fully adjusted model, the so-called "renal risk factors" were added to the model, and the use of active vitamin D (model 2: model 1 plus calcium, phosphate, PTH, eGFR, proteinuria, and use of active vitamin D).
Only two studies have investigated the use of active vitamin D analogs vs. supplemental vitamin D in CKD.
Firstly, the use of active vitamin D analogues in transplant patients with persistent hypercalcemic hyperparathyroidism is limited by hypercalcemia.
Similar results were reported by others in dialysis patients despite extensive use of active Vitamin D preparations [ 24].
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Alfacalcidol [1α(OH)D3; ALF] is a prodrug of active vitamin D3, a Ca-regulating hormone, and is frequently used in several countries to treat osteoporosis.
The in vivo production of active vitamin D in humans requires the conversion of 7-dehydro-cholesterol into vitamin D3 [39]–[42].
CYP24A1 is involved in the metabolism of active vitamin D compounds into inactive metabolites.
Reduced synthesis of active vitamin D contributes to secondary hyperparathyroidism.
Both an adequate vitamin D supply and the administration of active vitamin D metabolites could counteract and inhibit important mechanisms of bone loss in rheumatoid arthritis and should be used as an adjuvant therapeutic principle in this disease.
More suggestions(15)
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