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One obvious exit strategy that can prevent catastrophic losses is the use of a trailing exit commonly known as a "stop loss order".
Furthermore, inhibition of TRAIL bioactivity of the scFv scTRAIL by the use of a TRAIL-neutralizing antibody led to complete restoration of cell viability of Colo205 and HT1080 cells.
Dependability was obtained through use of an audit trail.
Study confirmability was promoted through the use of an audit trail including notes on analytic decisions, investigator triangulation, and member checking.
Although we did not find reports that describe the use of mitoxantrone as a TRAIL sensitizer, mitoxantrone has been demonstrated to possess synergistic relationship with Tumor Necrosis Factor (TNF) for inducing apoptosis in cells [ 51, 52].
Numerous studies have demonstrated the potential use of TRAIL as a cancer therapeutic and a number of TRAIL gene therapy strategies using recombinant viral vectors are described in the literature [ 3- 19].
In this speculative case, the use of TRAIL death receptor-specific TRAIL mutants could serve as an option to reduce potential side effects related to activation of the TRAIL death receptor type not relevant for apoptosis induction in the targeted tumor type.
Despite the fact that TRAIL can potently induce tumor cell apoptosis, TRAIL resistance observed in some cancer cells critically challenges the use of TRAIL as a gene therapy agent.
Despite this promising feature, TRAIL resistance observed in cancer cells seriously challenged the use of TRAIL as a death ligand in gene therapy.
Thus we went on and proposed a feasible therapeutic strategy for stroke, based on the use of a monoclonal antibody against TRAIL as a potential compound to be used in stroke intervention.
The group even makes use of its trail food, cooking a Wednesday-night meal of bulgur wheat with peanut sauce on camp stoves in a parking garage next to the hotel.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com