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Consequently, use of a standardization factor that eliminates expression variability linked to differential sample composition and differential gene expression in the various structures proved to be highly efficient for reducing inter-sample data scatter (Fig. 4) and, thereby, for identifying pathological biomarkers (Fig. 5).
The reason for using a two-trait model, instead of a single-trait model, was that the DRP had different scales in the two populations due to the use of a standardization procedure in the NH population.
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A limitation of the study is the lack of additional information about the cases, in particular their age, not allowing the use of a direct standardization method to account for the changing age-structure of the population, giving rise to potential bias due to the higher vulnerability of ageing populations to heat stress [ 2].
The portability and use of such standardization for full-text industry-standard protocols has not been studied in-depth.
Figure 1C depicts a causal relation between both PCBs and serum lipids with the outcome, and a noncausal association between PCBs and serum lipids resulting from a common ancestor, A. Use of the standardization model will be valid for this situation only if the standardization completely accounts for the association between PCB and serum lipids.
Clinical implementation of such a gene set would require regulatory and other issues to be resolved, including finalization of an ideal diagnostic set and use of a common platform to allow standardization, manufacturing, and quality control.
But the use of other standardization approach such as linear instead of natural break (Jenks) can be improved for map comparison and accuracy assessment purposes.
As elegantly outlined in the review, Sacks describes the history of the measurement of HbA1c, the process leading to standardization to DCCT/NGSP numbers, and the rationale for the global use of International Federation of Clinical Chemistry and Laboratory Medicine IFCCC) standardization.
With the labor shortages prevalent in the building industry, prefabrication together with the greater use of standardization and modular flat design are now the essential principles in the design of standard domestic blocks in Hong Kong.
For this purpose, we make use of the ongoing standardization initiatives for LAS Land Administrationn Domain Model: LADM) and IACS/LPIS (LPIS Core Model: LCM).
15 An exception is the use of standardization through (11) which implicitly refer to the practise of the 'NPL score' test statistic (Kruglyak et al. 1996; Ängquist, 2007).
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