The use of a replication-defective virus-based vector allowed us to deposit the test antigen, ovalbumin, in skeletal muscle, while transgenic CD8+ T cells expressing an ovalbumin-specific antigen receptor made a local and systemic immune response.
A second study population of patients with RA (n = 259, median age of 55.0 years) with early disease (median disease duration of 12 months) was used in a replication study of the association of TGFB1 polymorphism with IHD.
Despite the overall similarity between ES and TS, the use of a candidate-based replication timing assay allows loci that are subject to chromatin re-modelling events early in mammalian development to be readily identified.
Besides the impact of network size in grid and random topologies, another important point that we address is to determine the benefit of using a replication mechanisms in opportunistic scenarios.
This argument demonstrates a lack of understanding of the profound difference between the use of replication as a mechanism to assess reliability and the methods used to assess validity for peer-reviewed published academic studies, whereas GLP was instituted with the expectation that this type of verification would not occur.
The reference model in Section "Data infrastructure reference model" gives the basic blueprint with abstract entities and relationships that are more concrete in this section and focussed on the specific use case of a 'data replication service'.
First, our results indicate a clinical potential for the use of the replication marker, particularly for drug monitoring.
However, as results from multimorbidity studies might differ depending on the data set used [ 34], a replication of our study using other data sources should also be useful.
For example, a study of three related diseases or phenotypes suggests the use of three replication groups.
The data matrix was subjected to NONA [ 39] analyses, employing a heuristic parsimony analysis, with options set to hold 10000 trees, perform 1000 replications with one starting tree replication, and use of a multiple TBR + TBR search strategy.
This chapter discusses the use of attenuated replication competent adenoviruses (ARCAs) for the treatment of prostate cancer.
