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A dose of 2×10 gc/kg of AAV8 encoding human factor IX was delivered intravenously safely and effectively in a clinical trial in subjects with hemophilia B. An additional feature to consider in translating our findings to clinical applications is the use of a regulated expression system, which would enable turning UCn2 expression on or off at will.
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The main concerns here are adequate cooling, and importantly, use of a DC regulated power supply.
Another pet peeve is the media's use of "lightly regulated" and "highly leveraged" to describe hedge funds, which Mr. Redleaf says are "differently" regulated.
Here, we describe two systems that make use of GDEPT, regulated by radiation or hypoxic-responsive promoters.
Broadly speaking, the use of silk was regulated by a very precise code in China.
In the view of Taylor et al. [40, 46], alexithymia reflects a disturbance within the context of affective regulation, i.e. in the capacity to cognitively make use of and regulate feelings; such a skill ought to be acquired in the early years of development and, in this sense, it has a role in determining the quality of the relationship with the primary caregiver.
The use of force is regulated by the rules and principles of international humanitarian law.
The symbiotic relationship between these three crops makes efficient use of farmland, regulates moisture and sunlight, and eliminates the need for fertilizers and pesticides.
However, The Guardian made it clear in an editorial on Monday that it opposed the use of "a medieval instrument" to regulate the press.
The control design phase is based on the use of a cascade control to regulate the position with an inner speed control loop.
An example is the use of a "talking stick" to regulate discussion and decision making in a group of peers, with the rules that the talking stick gets passed around and only the person who is holding the stick is allowed to talk (Nerburn 1999).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com